Open-source R packages implementing statistical methodology.
Statistical Genetics
COAST / AllelicSeries
Gene-level rare-variant association testing designed to identify allelic series in which increasingly deleterious coding variants have increasingly large phenotypic effects.
Robust Inference
RNOmni
Robust association testing for continuous traits with non-normal residuals using direct, indirect, and omnibus rank-based inverse normal transformation tests.
Prediction-Based Inference
SurrogateRegression
Joint modeling of a partially observed target outcome and a correlated surrogate outcome to improve power while maintaining valid inference.
Missing Data
MGMM
Missingness-aware Gaussian mixture modeling for parameter estimation, clustering, and imputation with incomplete multivariate data.
Event-Time Analysis
Temporal
Parametric time-to-event analysis and between-group comparisons of interpretable survival summaries, including mean, median, and restricted mean survival.
Recurrent Events
MCC
Estimation and inference for mean cumulative count curves and their areas for recurrent-event outcomes subject to censoring and terminal events.